余靈珊助理教授

研究領域：生醫檢測晶片、定溫核酸增幅技術、流行病學、生物資訊學

最高學歷：英國帝國理工學院生命科學博士

E-mail：lingshanyu@mail.nsysu.edu.tw / lingshan0120@gmail.com

連絡電話：07-5252000 #7204

辦公室：IR6001

個人網頁：https://lingshanyu.squarespace.com/

學歷

英國帝國理工學院電機學系博士後研究員

2016-2019

英國帝國理工學院生命科學系博士

2012-2016

英國帝國理工學院生命科學系碩士

2010-2011

專業

生物感測器、CRISPR檢測技術開發、定溫核酸增幅技術、生物資訊學

學術榮譽

• 2024 台灣化學感測器科技協會(ACST)113年度學術獎章之優秀年輕學者論文獎

• 2024教育部智慧晶片系統應用創新競賽銀獎

• 2023 中山大學學術研究團隊績優教師

• 2023 產學績優獎 (技術轉移)

• 2023 醫學院優良導師

• 2022 中山大學產學績優獎 (產學合作)

• 2021-2023 中山大學新進教師獎勵

講授科目

• 新興病原微生物與其抗藥性檢測

• 創新生技產業現況與展望

• 生技醫藥研發與技術特論

• 生物資訊學及其應用

• 科技論文寫作

• 生物醫學科技導論

• 書報討論

專利及專書

專利

1. WO2019234252A1. Method for detecting a tandem repeat. (Georgiou P., Yu L.S., Cardenas, K.M., Fisher M.C., Manzano, J.R., Moser, N.)

2. WO2019234251A1. Method for detecting a single nucleotide polymorphism (SNP) using LAMP and blocking primers. (Georgiou P, Malpartida K, Yu, L.S., Baum J., N. Miscourides, Manzano, J.R.)

產品

1. 新冠肺炎定溫檢測試劑(台灣防疫專案核准製造第1096821155號) (歐盟CE IVDD 98/79/EC認證) (技轉)

期刊論文

1. Hsin-Ying Ho, Wei-Sin Kao, Piyush Deval, Chia-Yen Dai, Yen-Hsu Chen, Ming-Lung Yu, Che-Hsin Lin, Ling-Shan Yu* (2023). Rapid and sensitive LAMP/CRISPR-powered diagnostics to detect different hepatitis C virus genotypes using an ITO-based EG-FET biosensing platform. Sensors and Actuators: B. Chemical, 394, 134278. (Instruments & Instrumentation = 1/76, Q1) (SCI, impact factor = 8.4). (corresponding author)

2. Jing-Wen Guo, Hsin-Ying Ho, Chia-Yen Dai, Yen-Hsu Chen, Ming-Lung Yu, Ling-Shan Yu* (2024) Single-Tube, Single-Strip Lateral-Flow Assays Utilizing Loop-Mediated Isothermal Amplification for Simultaneous Hepatitis B and C Viral Detection. Journal of Medical Virology, 96(6), e29721. (Virology = 4/41, Q1) (SCI, impact factor = 6.8)(corresponding author)

3. Wei-Sin Kao, Ling-Shan Yu, Che-Hsin Lin. (2023). Rapid Fluorescence-free Detection of DNA Loop-mediated Isothermal Amplification on Bare ITO Surface Under EG-FET Scheme. IEEE Sensors Journal, 23(13), 13876-13881. (Instruments & Instrumentation = 15/63, Q1) (SCI, impact factor = 4.3).

4. Chia-Hsu Hsieh, Chih-Hsien Huang, Jia-Huei Lin, Ling-Shan Yu, and I-Yu Huang (2023). Development of an EGFET microsensor with 3D structure for high-specificity cardiac troponin I detection. Journal of Micromechanics and Microengineering, 33(4), 045001. (Engineering electrical & electronic = 162/275) (SCI, impact factor = 2.3). (co-corresponding author)

5. Yu-Yao Chiu, Chun-Yu Lin, Ling-Shan Yu, Wen-Hung Wang, Chung-Hao Huang, Yen-Hsu Chen (2023). The association of obesity and dengue severity in hospitalized adult patients. Journal of Microbiology, Immunology and Infection, 56(2), 267-273. (Immunology = 34/161, Infectious diseases = 16/96, Q1) (SCI, impact factor = 7.4).

6. Nicolas Moser*, Ling-Shan Yu*, Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Anselm Au, Paul Arkell, Chiara Cicatiello, Ahmad Moniri, Luca Miglietta, Wen-Hung Wang, Sheng-Feng Wang, Alison Holmes, Yen-Hsu Chen and Pantelis Georgiou. (2022). Quantitative detection of dengue serotypes using a smartphone-connected handheld lab-on-chip platform. Frontiers in Bioengineering and Biotechnology, 10, 892853. (Multidisciplinary sciences = 16/73, Q1) (SCI, impact factor = 5.7). (co-1st author)

7. Ling-Shan Yu*, Sheng-Yeh Chou, Hsing-Yu Wu, Yu-Cheng Chen, Yen-Hsu Chen (2021). Rapid and semi-quantitative colorimetric loop-mediated isothermal amplification detection of ASFV via HSV color model transformation. Journal of Microbiology, Immunology and Infection, 54(5), 963-970. (Immunology = 34/161, Infectious diseases = 16/96, Q1) (SCI, impact factor = 7.4). (corresponding author & first author)

8. Ling-Shan Yu, Jesus Rodriguez-Manzano, Nicolas Moser, Kenny Malpartida Cardenas, Nicholas Miscourides, Thomas Sewell, Tatiana Kochina, Matthew C. Fisher and Pantelis Georgiou. (2020). Rapid detection of azole-resistant Aspergillus fumigatus in clinical and environmental isolates by use of a lab-on-a-chip diagnostic system. Journal of Clinical Microbiology, 58(11), 10-1128. (Microbiology = 17/135, Q1) (SCI, impact factor = 9.4). (first author)

9. M. Kalofonou, K M-Cardenas, G. Alexandrou, J. R-Manzano, Ling-Shan Yu, N. Moser, Allsopp, R. L.T. K. Gleason, K. Goddard, D. Fernandez-Garcia, K. Page, P. Georgiou, S. Ali, R. Coombes, J. Shaw, C. Toumazou (2020). A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p. H1047R breast cancer mutation. Scientific reports, 10(1), 4553. (Multidisciplinary Sciences = 22/73, Q2) (SCI, impact factor = 4.6).

10. Kai-Hong Tu*, Ling-Shan Yu*, Zong-Han Sie, Han-Yi Hsu, Khuloud T Al-Jamal, Julie Tzu-Wen Wang, Ya-Yu Chiang (2020). Development of real-time transendothelial electrical resistance monitoring for an in vitro blood-brain barrier system. Micromachines, 12(1), 37. (Chemistry, Analytical = 29/86, Q2) (SCI, impact factor = 3.4). (co-1st author)

11. Ling-Shan Yu, Jesus R-Manzano, Kenny M-Cardenas, Thomas Sewell, Oliver Bader, Darius Armstrong-James, Matthew C.Fisher and Pantelis Georgiou (2019). Rapid and sensitive detection of azole-resistant Aspergillus fumigatus by tandem repeat loop-mediated isothermal amplification. The Journal of Molecular Diagnostics, 21(2), 286-295. (Pathology = 8/87, Q1) (SCI, impact factor = 4.1). (first author)

12. K. M-Cardenas, N. Miscourides, J. R-Manzano, Ling-Shan Yu, J. Baum and P. Georgiou (2019). Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform. Biosensors and Bioelectronics, 145, 111678. (Biotechnology & applied microbiology = 7/158, Q1) (SCI, impact factor = 12.6).

13. Ahmad M.,Jesus R. M., Kenny M.C., Ling-Shan Yu, Xavier Didelot, Alison Holmes, Pantelis Georgiou (2019). Framework for dna quantification and outlier detection using multidimensional standard curves. Analytical chemistry, 91(11), 7426-7434. (Chemistry, analytical = 7/86, Q1) (SCI, impact factor = 7.4).

14. Nicholas Miscourides, Ling-Shan Yu, Jesus Rodriguez-Manzano and Pantelis Georgiou (2018). A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection. IEEE transactions on biomedical circuits and systems, 12(5), 1202-1214. (Engineering, electrical & electronic = 68/275, Q1) (SCI, impact factor = 5.1).

15. K. M-Cardenas, J. R-Manzano, Ling-Shan Yu, Michael Delves, Chea Nguon, Kesinee Chotivanich, Jake Baum, Georgiou Pantelis (2018). Allele-specific isothermal amplification method using unmodified self-stabilizing competitive primers. Analytical chemistry, 90(20), 11972-11980. (Chemistry, analytical = 7/86, Q1) (SCI, impact factor = 7.4).

16. Ling-Shan Yu, Nicolas Moser, Jesus Rodriguez-Manzano, Sheng-Fan Wang, Yen-Hsu Chen, Alison Holmes and Pantelis Georgiou (2018). Engineering rapid and sensitive electronic diagnostics for dengue and Zika viruses. International Journal of Infectious Diseases, 73, 166. (Infectious diseases = 13/96, Q1) (SCI, impact factor = 8.4). (first author)

17. C-Sheng Lin, Duncan W. E. Allsopp, Kate Cavanagh, Hei Chit Leo Tsui, Ling-Shan Yu, Wang-Nan Wang, Andrei Mihai, Bin Zou, Michelle A. Moram (2021). About 335 nm Ultraviolet Emissions Obtained from Simple Metal–Insulator–Semiconductor Light‐Emitting Tunnel Diodes. physica status solidi (a), 218(2), 2000524. (Materials Science, Multidisciplinary = 256/344, Q3) (SCI, impact factor = 4.6).

研究計畫、國科會計畫、產學合作計畫

國科會計畫

• 113-116年 CRISPR-based diagnostic platform for antibiotic misuse: rapid differentiation of viral and bacterial infections (guiding antibiotic use) and precision antimicrobial resistance screening

• 110-113年 Development of biosensing platform for the LAMP/CRISPR-based rapid screening of infectious mutant strains: COVID-19 as an example

產學合作計畫

• 110年教育部高教深耕智慧生醫感測群 (子計畫主持人)

• 110年經濟部SBIR計畫(產學合作)(計畫主持人)

• 111年教育部高教深耕智慧生醫感測群 (子計畫主持人)

• 111年中山長庚合作計畫 (計畫主持人)

• 111年中山大學高醫合作計畫 (計畫主持人)

• 111年經濟部SBIR計畫 (產學合作)(計畫主持人)

• 112年經濟部SBIR計畫 (產學合作)(計畫主持人)

• 113年教育部高教深耕潛力國際研究群 (子計畫主持人)

• 113年中山高醫加值計畫(計畫主持人)

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余靈珊 助理教授

余靈珊助理教授