孫羽佑助理教授

研究領域：神經細胞生物學、神經免疫學、血管生物學

最高學歷：臺北醫學大學醫學科學研究所博士

E-mail：yuyosun@mail.nsysu.edu.tw / yuyosun42@gmail.com

連絡電話：07-5252000 #7205

辦公室：IR6001

個人網頁：ORCID

學經歷

Assistant Professor, National Sun Yat-sen University, Kaohsiung, Taiwan

2021

Assistant Professor, University of Virginia School of Medicine, Charlottesville, VA, USA

2018

Assistant Professor, Emory University School of Medicine, Atlanta, GA, USA

2016

Research Associate, Emory University School of Medicine, Atlanta, GA, USA

2015

Postdoctoral Fellow, Emory University School of Medicine, Atlanta, GA, USA

2012

Research Fellow, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

2010

Research Fellow, National Yang-Ming University, Taipei, Taiwan

2010

Ph. D., Institute of Medical Sciences, Taipei Medical University

專業

腦中風與血管病變、腦血流調控、神經免疫、分子和細胞神經生物、神經保護藥物開發

學術榮譽

American Heart Association (AHA) Postdoctoral Fellowship, 14POST18720029

2014

American Heart Association (AHA) Scientist Development Grant, 17SDG3370003

2017

National Institute of Neurological Disorders and Stroke grant, 1R21NS106592

2018

講授科目

• 神經疾病與藥物開發特論

• 醫藥研究動物模式與技術

• 生理調控與人類疾病

• 大分子藥物開發特

• 生技醫藥研發與技術特論

• 藥物開發通論

• 生物化學

專利及專書

美國專利US patent application #20160317473
Method of treating or preventing brain damage due to hypoxic-ischemia

期刊論文

Selected Peer-Reviewed Publications (since 2020)

1. H-J Tsay, Y-L Gan, Y-H Su, Y-Y Sun, H-H Yao, H-W Chen, Y-T Hsu, J T-A Hsu, H-D Wang, F-S Shie (2024). Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice. Biomedicine & Pharmacotherapy. 173:116404.

2. EJ Bian, C-W Chen, C-M Cheng, C-Y Kuan*, Y-Y Sun* (2023). Impaired post-stroke collateral circulation in sickle cell anemia mice. Frontiers in Neurology. 14:1215876. *corresponding authors. Chen, N.-F., Kuo, H.-M., Lin, H.-Y., Wen, Z.-H., Chen, W.-F. STAT3 phosphorylation inhibitor Bt354 exhibits anti-neoplastic activity in glioblastoma multiforme cells. Environmental Toxicology. 2024. https://doi.org/10.1002/tox.24178 (IF: 4.5, 16/94= 17.0% in Toxicology)

3. K-H Lin, J-Y Li, R-J Chen, T-U Chen, S-H Hsu, H-H Wang, H-Y Peng, Y-Y Sun, W-J Lu (2023). Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis. Thrombosis Research. 225:63-72.

4. W-J Lu, C-H Tsai, R-J Chen, L-T Huang, T-U Chen, L-C Chen, H-H Wang, H-Y Peng, Y-Y Sun, K-H Lin (2022). Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. Biomedicine & Pharmacotherapy. 153:113531.

5. Y-Y Sun*, H-W Yao, H-R Chen, C-W Chen, M Kinkaid, C-Y Kuan*, (2022). Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia. Neurobiology of Disease. 171:105802. *corresponding authors.

6. H-R Chen, C-W Chen, Y-M Kuo, C-W Chen, B Chen, IS Kuan, H Huang, J Lee, N Anthony, C-Y Kuan*, Y-Y Sun* (2022). Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics. 12(2):512-529. *corresponding authors.

7. Changjun Yang, BP Lavayen, L Liu, BD Sanz, KM DeMars, J Larochelle, M Pompilus, M Febo, Y-Y Sun, Y-M Kuo, M Mohamadzadeh, SA Farr, C-Y Kuan, AA Butler, E Candelario-Jalil (2021). Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism. Redox Biology, 22;48:102197.

8. K Bisht, KA Okojie, K Sharma, DH Lentferink, Y-Y Sun, H-R Chen, JO Uweru, S Amancherla, Z Calcuttawala, AB Campos-Salazar, B Corliss, L Jabbour, J Benderoth, B Friestad, WA Mills 3rd, BE Isakson, ME Tremblay, C-Y Kuan, U B Eyo (2021). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature Communications, 12(1):5289.

9. T-L Shih, K-H Lin, R-J Chen, T-Y Chen, W-T Kao, J-W Liu, H-H Wang, H-Y Peng, Y-Y Sun, W-J Lu (2021). A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine, 25(19):9434-9446.

10. H-R Chen, X Zhang-Brotzge, YM Morozov, Y Li, S Wang, H Zhang, IS Kuan, EM Fugate, H Mao, Y-Y Sun, P Rakic, DM. Lindquist, T DeGrauw, C-Y Kuan (2021). Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight, 8;6(17):e140173.

11. VM Sciortino, A Tran, N Sun, R Cao, T Sun, Y-Y Sun, P Yan, F Zhong, Y Zhou, C-Y Kuan, J-M Lee, S Hu (2021). Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy. Journal of Cerebral Blood Flow and Metabolism. 271678X211034096. doi:10.1177/0271678X211034096.

12. C-Y Kuan*, H-R Chen, N Gao, Y-M Kuo, C-W Chen, D Yang, MM Kinkaid, E Hu, Y-Y Sun*. (2021) Brain-Targeted Hypoxia-Inducible Factor Stabilization Reduces Neonatal Hypoxic-Ischemic Brain Injury. Neurobiology of Disease. 148, 105020. *corresponding authors.

13. H-R Chen, C-W Chen, N Mandhani, JC Short-Miller, MR Smucker, Y-Y Sun, C-Y Kuan. (2020) Monocytic Infiltrates Cause Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience. 40(49): 9386-400.

14. H-R Chen, Y-Y Sun, C-W Chen, Y-M Kuo, IS Kuan, Z-Z Li, MR Smucker, C-Y Kuan. (2020) Fate-Mapping via CCR2CreER Mice Reveals Monocyte-to-Microglia Transition in Development and Neonatal Stroke. Science Advances. 6(35): eabb2119.

15. Y-Y Sun*, Y-M Kuo*, H-R Chen, JC Short-Miller, MR Smucker, C-Y Kuan. (2020) A Murine Photothrombotic Stroke Model with an Increased Fibrin Content and Improved Responses to tPA-Lytic Treatment. Blood Advances. 4(7): 1222-31. *equally contributing first authors.

研究計畫、國科會計畫、產學合作計畫

國科會計畫

從基礎到臨床: 乙型地中海貧血中風預防與急性治療之研究
Bench to Bedside: Primary Stroke Prevention and Acute Therapy in beta-Thalassemia (MOST 111-2320-B-110 -003 -MY2)

微神經膠與血管內皮細胞對於高血壓引起認知功能障礙之研究
Microglia-Vascular Endothelium Interactions in Hypertension-Related Cognitive Impairment (NSTC 113-2320-B-110-010)

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孫羽佑 助理教授

孫羽佑助理教授