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Dr. Yu-Yo Sun Assistant Professor

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Research Areas: Molecular and Cellular Neurobiology, Neuroimmunology, Vascular Biology

E-mail: yuyosun@mail.nsysu.edu.tw/yuyosun42@gmail.com

Web Page: ORCID

Room: IR6001

Tel: 07-5252000 ext. 7205

Education & Positions & Employments
Assistant Professor, National Sun Yat-sen University, Kaohsiung, Taiwan 2021
Assistant Professor, University of Virginia School of Medicine, Charlottesville, VA, USA 2018
Assistant Professor, Emory University School of Medicine, Atlanta, GA, USA 2016
Research Associate, Emory University School of Medicine, Atlanta, GA, USA 2015
Postdoctoral Fellow, Emory University School of Medicine, Atlanta, GA, USA 2012
Research Fellow, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA 2010
Research Fellow, National Yang-Ming University, Taipei, Taiwan 2010
Ph. D., Institute of Medical Sciences, Taipei Medical University
Specialty
Stroke and vascular disease, CBF regulation, Neuroimmunology, Molecular and cellular neurobiology, Drug development in Neuroprotection
Honors & Awards
American Heart Association (AHA) Postdoctoral Fellowship, 14POST18720029 2014
American Heart Association (AHA) Scientist Development Grant, 17SDG3370003 2017
National Institute of Neurological Disorders and Stroke grant, 1R21NS106592 2018
Courses
• rug Development in Central Nervous System (CNS) Disorders
• The Animal Model and Technology in Biopharmaceutical Research
• Body Processes and Disease Progression
• Development of Macromolecular Therapeutics
• Research and Technologies in The Development of Biopharmaceuticals
• General Theory of Drug Discovery
• Biochemistry
Patents
US patent application #20160317473
Method of treating or preventing brain damage due to hypoxic-ischemia 
Selected publication
Selected Peer-Reviewed Publications (since 2020)
1. H-J Tsay, Y-L Gan, Y-H Su, Y-Y Sun, H-H Yao, H-W Chen, Y-T Hsu, J T-A Hsu, H-D Wang, F-S Shie (2024). Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice. Biomedicine & Pharmacotherapy. 173:116404. 
2. EJ Bian, C-W Chen, C-M Cheng, C-Y Kuan*, Y-Y Sun* (2023). Impaired post-stroke collateral circulation in sickle cell anemia mice. Frontiers in Neurology. 14:1215876. *corresponding authors. Chen, N.-F., Kuo, H.-M., Lin, H.-Y., Wen, Z.-H., Chen, W.-F. STAT3 phosphorylation inhibitor Bt354 exhibits anti-neoplastic activity in glioblastoma multiforme cells. Environmental Toxicology. 2024. https://doi.org/10.1002/tox.24178 (IF: 4.5, 16/94= 17.0% in Toxicology)
3. K-H Lin, J-Y Li, R-J Chen, T-U Chen, S-H Hsu, H-H Wang, H-Y Peng, Y-Y Sun, W-J Lu (2023). Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis. Thrombosis Research. 225:63-72.
4. W-J Lu, C-H Tsai, R-J Chen, L-T Huang, T-U Chen, L-C Chen, H-H Wang, H-Y Peng, Y-Y Sun, K-H Lin (2022). Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. Biomedicine & Pharmacotherapy. 153:113531.
5. Y-Y Sun*, H-W Yao, H-R Chen, C-W Chen, M Kinkaid, C-Y Kuan*, (2022). Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia. Neurobiology of Disease. 171:105802. *corresponding authors. 
6. H-R Chen, C-W Chen, Y-M Kuo, C-W Chen, B Chen, IS Kuan, H Huang, J Lee, N Anthony, C-Y Kuan*, Y-Y Sun* (2022). Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics. 12(2):512-529. *corresponding authors.
7. Changjun Yang, BP Lavayen, L Liu, BD Sanz, KM DeMars, J Larochelle, M Pompilus, M Febo, Y-Y Sun, Y-M Kuo, M Mohamadzadeh, SA Farr, C-Y Kuan, AA Butler, E Candelario-Jalil (2021). Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism. Redox Biology, 22;48:102197.
8. K Bisht, KA Okojie, K Sharma, DH Lentferink, Y-Y Sun, H-R Chen, JO Uweru, S Amancherla, Z Calcuttawala, AB Campos-Salazar, B Corliss, L Jabbour, J Benderoth, B Friestad, WA Mills 3rd, BE Isakson, ME Tremblay, C-Y Kuan, U B Eyo (2021). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature Communications, 12(1):5289. 
9. T-L Shih, K-H Lin, R-J Chen, T-Y Chen, W-T Kao, J-W Liu, H-H Wang, H-Y Peng, Y-Y Sun, W-J Lu (2021). A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine, 25(19):9434-9446.
10. H-R Chen, X Zhang-Brotzge, YM Morozov, Y Li, S Wang, H Zhang, IS Kuan, EM Fugate, H Mao, Y-Y Sun, P Rakic, DM. Lindquist, T DeGrauw, C-Y Kuan (2021). Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight, 8;6(17):e140173. 
11. VM Sciortino, A Tran, N Sun, R Cao, T Sun, Y-Y Sun, P Yan, F Zhong, Y Zhou, C-Y Kuan, J-M Lee, S Hu (2021). Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy. Journal of Cerebral Blood Flow and Metabolism. 271678X211034096. doi:10.1177/0271678X211034096. 
12. C-Y Kuan*, H-R Chen, N Gao, Y-M Kuo, C-W Chen, D Yang, MM Kinkaid, E Hu, Y-Y Sun*. (2021) Brain-Targeted Hypoxia-Inducible Factor Stabilization Reduces Neonatal Hypoxic-Ischemic Brain Injury. Neurobiology of Disease. 148, 105020. *corresponding authors. 
13. H-R Chen, C-W Chen, N Mandhani, JC Short-Miller, MR Smucker, Y-Y Sun, C-Y Kuan. (2020) Monocytic Infiltrates Cause Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience. 40(49): 9386-400. 
14. H-R Chen, Y-Y Sun, C-W Chen, Y-M Kuo, IS Kuan, Z-Z Li, MR Smucker, C-Y Kuan. (2020) Fate-Mapping via CCR2CreER Mice Reveals Monocyte-to-Microglia Transition in Development and Neonatal Stroke. Science Advances. 6(35): eabb2119. 
15. Y-Y Sun*, Y-M Kuo*, H-R Chen, JC Short-Miller, MR Smucker, C-Y Kuan. (2020) A Murine Photothrombotic Stroke Model with an Increased Fibrin Content and Improved Responses to tPA-Lytic Treatment. Blood Advances. 4(7): 1222-31. *equally contributing first authors. 
NSTC grants
國科會計畫
從基礎到臨床: 乙型地中海貧血中風預防與急性治療之研究
Bench to Bedside: Primary Stroke Prevention and Acute Therapy in beta-Thalassemia (MOST 111-2320-B-110 -003 -MY2)
微神經膠與血管內皮細胞對於高血壓引起認知功能障礙之研究
Microglia-Vascular Endothelium Interactions in Hypertension-Related Cognitive Impairment  (NSTC 113-2320-B-110-010)
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