施柏漳助理教授

研究領域：蛋白質降解藥物開發、靶向蛋白降解、藥物化學

最高學歷：英國倫敦大學學院藥學院博士

E-mail：po-chang.shih.23@mail.nsysu.edu.tw

連絡電話：07-5252000 #7207

辦公室：IR6001

個人網頁：https://sites.google.com/view/shih-lab/home

學經歷

國立中山大學醫學院生技醫藥研究所助理教授

2023/8-至今

美東京大學/日本學術振興會 JSPS 研究員

2022/04-2023/06

高雄長庚醫院博士後研究人員

2021/09-2022/04

心悅生醫股份有限公司

2020/02-2021/08

英國倫敦大學學院藥學院博士

專業

小分子藥物開發、蛋白質降解藥物開發、藥物化學、靶像蛋白降解

學術榮譽

國立中山大學新進教師獎勵

2023-2024

JSPS Postdoctoral Fellowship (Standard)

台灣科技部博士創新計畫

UCL School of Pharmacy Best PhD Student Publication Award 2018, UK

Poster Prize at 10th BMCS Biological and Medicinal Chemistry Postgraduate Symposium, UK

中華民國斐陶斐榮譽會員

講授科目

• 毒理學

• 藥物代謝與藥物動力學

• 蛋白質降解藥物開發特論 (一)

• 蛋白質降解藥物開發特論 (二)

• 雙功能分子藥物開發專題研究（一）

• 雙功能分子藥物開發專題研究（二）

專利及專書

Chih-Hung Lin, Po-Chang Shih, Guochuan Emil Tsai. Perspective Chapter-NMDA Treatments for CNS Disorders (2021) IntechOpen

期刊論文

• Wen, Z.-H., Chang, L., Yang, S.-N., Yu, C,-L., Tung, F.-Y., Kuo, H.-M., Lu, I.-C,. Wu, C.-Y.,Shih, P.-C., Chen, W.-F, Chen, N.-F. The anti-angiogenic and anti-vasculogenic mimicry effects of GN25 in endothelial and glioma cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2024. https://doi.org/10.1016/j.bbamcr.2024.119799 (IF: 4.6, 74/313= 23.6% in Biochemistry & Molecular Biology)

• Chiang, Y.-C., Selvam P, Liu, Y.-X., Shih, P.-C., Chen, N.-F., Kuo, H.-M., Lin, H.-Y., Wen, Z.-H., Chen, W.-F. STAT3 phosphorylation inhibitor Bt354 exhibits anti-neoplastic activity in glioblastoma multiforme cells. Environmental Toxicology. 2024. https://doi.org/10.1002/tox.24178 (IF: 4.5, 16/94= 17.0% in Toxicology)

• Shih, P.-C., Naganuma, M., Tsuji G., Demizu, Y., Naito, M. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. Bioorganic and Medicinal Chemistry. 2023. https://doi.org/10.1016/j.bmc.2023.117507 (IF: 3.5, 12/52 = 23.1% in Organic Chemistry)

• Shih, P.-C., Naganuma, M., Demizu, Y., Naito, M. Current status of oligonucleotide-based protein degraders. Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15030765 (IF: 5.4, 51/277= 18.2% in Pharmacology & Pharmacy)

• Wen, Z.-H.*, Kuo, H.-M.*, Shih, P.-C.*, Hsu, L.-C., Chuang, J. M.-J., Chen, N.-F., Sun, H.-W., Liu, H.-T., Sung, C.-S., Chen, W.-F. Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells. Biomedicine & Pharmacotherapy. 2023 https://doi.org/10.1016/j.biopha.2023.114359 (IF: 7.5, 23/277= 8.1% in Pharmacology & Pharmacy)
*The authors contributed equally.

• Mao, Y.-W., Lu, L.-P., Shih, P.-C., Hsiao, J.-F., Wu, V., Tsai, G. E. Ultrapure and potent tannic acid (UPPTA) is a novel inhibitor of D-amino acid oxidase to improve the N-methyl-D-aspartate function of CNS disorders. Phytomedicine

• Hsu S.-Y., Wen, Z.-H., Shih, P.-C., Kuo, H.-M., Lin, S.-C., Liu, H.-T., Lee, Y.-H., Wang, Y.-J., Chen, W.-F., Chen, N.-F. Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells. Antioxidants. 2022; https://doi.org/10.3390/antiox11081433 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)

• Kuo, T.-J., Jean, Y.-H., Shih, P.-C., Cheng, S.-Y., Kuo, H.-M., Lee, Y.-T., Lai, Y.-C., Tseng, C.-C., Chen, W.-F., and Wen, Z.-H. Stellettin B Induces Autophagic Cell Death and Apoptosis through Endoplasmic Reticulum in Human Oral Cancer. International Journal of Molecular Sciences. 2022; https://doi.org/10.3390/ijms23158813 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)

• Shih, P.-C.*, Mao, Y.-W.*, Hu, J.-W.*, Hsieh, H.-Y.*, Shih, T.-M.*, Lu, L.-P.*, Chang, W.-H.*, Huang, C.-H.*, Lin, C.-H.*, Lin, C.-H., Tan, P., Yang, Y.-C., Chien, M.-H., Su, C.-C., Ye, C.-H., Chuang, P.-Y., Hsieh, T.-L., Wang, C.-C., Hsieh, P.-S., Chou, T.-Y., Tsai, G. E. Development of the ultrapure and potent tannic acid as an orally bioavailable, pancoronal antiviral therapeutic. ACS Pharmacology & Translational Science. 2022; https://doi.org/10.1021/acsptsci.1c00264 (IF: 6.0, 25/366=6.8% in Pharmacology & Pharmacy) (被選為期刊封面、臨床試驗NCT04911777的臨床前數據發表)
*The authors contributed equally.

• Shih, P.-C.# The role of the STAT3 signaling transduction pathways in radioresistance. Pharmacology & Therapeutics. 2022; https://doi.org/10.1016/j.pharmthera.2022.108118 (IF: 13.5, 7/277=2.3% in Pharmacology & Pharmacy)
#First author and corresponding author.

• Chen, Y.-P.*, Shih, P.-C.*, Feng, C.-W., Wu, C.-C., Tsui, K.-H., Lin, Y.-H., Kuo, H.-M., and Wen, Z.-H. Pardaxin activates excessive mitophagy and mitochondria-mediated apoptosis in human ovarian cancer by inducing reactive oxygen species. Antioxidants. 2021; https://doi.org/10.3390/antiox10121883 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)
*The authors contributed equally.

• Lin, C.-H., Shih, P.-C., Tsai, G. E. Perspective Chapter: NMDA Treatments for CNS Disorders under the book title Ketamine Revisited - New Insights into NMDA Inhibitors. IntechOpen. 2021

• Ko, C.-Y.*, Shih, P.-C.*, Huang, P.-W., Lee, Y.-H., Chen, Y.-F., Tai M.-H., Liu, C.-H., Wen, Z.-H., Kuo, H.-M. Sinularin, an anti-cancer agent causing mitochondria-modulated apoptosis and cytoskeleton disruption in human hepatocellular carcinoma. International Journal of Molecular Sciences.2021; https://doi.org/10.3390/ijms22083946 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)
*The authors contributed equally.

• Shih, P.-C.#, Mei, K.-C. Role of STAT3 signaling transduction pathways in cancer stem cell-associated chemoresistance. Drug Discovery Today.2021; https://doi.org/10.1016/j.drudis.2020.11.032 (IF: 7.4, 24/277= 8.5 % in Pharmacology & Pharmacy)
#First author and corresponding author.

• Yuan, C.-H.*, Ma, Y.-L.*, Shih, P.-C.*, Chen, C.-T., Cheng, S.-Y., Pan, C.-Y., Jean, Y.-H., Chu, Y.-M., Lin, S.-C, Lai, Y,-C., Kuo, H,-M. The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells. Biochemical Pharmacology. 2020;. doi: 10.1016/j.bcp.2020.114064 (IF: 5.8, 40/277 = 14.3% in Pharmacology & Pharmacy)
*The authors contributed equally.

• Chen, Y.-F.*, Shih, P.-C.*, Kuo, H.-M.*, Yang, S.-N., Lin, Y.-Y., Chen, W.-F., Tzou, S.-J., Liu, H.-T., Chen, N.-F. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment. Cancer Medicine. 2020;. doi: 10.1002/cam4.3005 (IF: 4.0, 96/241 = 39.6% in Oncology)
*The authors contributed equally.

• Shih, P.-C.# Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains. Life Sciences. 2019; doi: 10.1016/j.lfs.2019.117241 (IF: 6.1, 35/277 = 12.5% in Pharmacology & Pharmacy)
#First author and corresponding author.

• Shih, P.-C., Yang, Y., Parkinson, G. N., Wilderspin, A. & Wells, G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 2018; doi: 10.18632/oncotarget.26013

研究計畫、國科會計畫、產學合作計畫

國科會計畫

112

離體發展高安全性、有效性並具臨床潛力的新穎STAT3蛋白質降解藥物

113-115

以新穎藥理機制離體開發抗神經性疼痛藥物

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施柏漳 助理教授

施柏漳助理教授