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Dr. Po-Chang Shih Assistant Professor

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Dr. Po-Chang Shih  Associate Professor

Research Areas：PROTAC development, targeted protein degradation, medicinal chemistry

E-mail：po-chang.shih.23@mail.nsysu.edu.tw

Web Page：https://sites.google.com/view/shih-lab/home

Room: IR6001

Tel：07-5252000 ext. 7207

 

Education & Positions & Employments
Assistant Professor, Institute of BioPharmaceutical Sciences College of Medicine, NSYSU, Taiwan 2023/8-now
JSPS Postdoctoral Fellow, The University of Tokyo/ Japan Society for the Promotion of Science 2022/04-2023/06
Postdoctoral Researcher, Kaohsiung Chang Gung Memorial Hospital 2021/09-2022/04
Postdoctoral Research Scientist, SyneuRx Lifesciences US Inc. & 2020/02-2021/08
PhD, UCL School of Pharmacy, University College London, UK
Specialty
Small Molecule Drug Discovery and Development, Protein Degrader Drug Discovery and Development, Medicinal Chemistry, Targeted Protein Degradation
Honors & Awards
NSYSU New Faculty Award, Taiwan 2023-2024
JSPS Postdoctoral Fellowship (Standard), Japan Society for the Promotion of Science, Japan
Fellow of LEAP Program of Ministry of Science and Technology, Taiwan
UCL School of Pharmacy Best PhD Student Publication Award 2018, UK
Poster Prize at 10th BMCS Biological and Medicinal Chemistry Postgraduate Symposium, UK
Honorary member of The Phi Tau Phi Scholastic Honor Society of Taiwan
Courses
• TOXIC RESPONSES OF ORGANS
• DRUG METABOLISM AND PHARMACOKINETICS
• TARGETED PROTEIN DEGRADATION BASED DRUG DEVELOPMENT (I)
• TARGETED PROTEIN DEGRADATION BASED DRUG DEVELOPMENT (II)
• INDEPENDENT STUDIES IN BIFUNCTIONAL MOLECULE DRUG DISCOVERY (I)
• INDEPENDENT STUDIES IN BIFUNCTIONAL MOLECULE DRUG DISCOVERY (II)
Patents
Chih-Hung Lin, Po-Chang Shih, Guochuan Emil Tsai. Perspective Chapter-NMDA Treatments for CNS Disorders (2021) IntechOpen
Selected publication
• Wen, Z.-H., Chang, L., Yang, S.-N., Yu, C,-L., Tung, F.-Y., Kuo, H.-M., Lu, I.-C,. Wu, C.-Y.,Shih, P.-C., Chen, W.-F, Chen, N.-F. The anti-angiogenic and anti-vasculogenic mimicry effects of GN25 in endothelial and glioma cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2024. https://doi.org/10.1016/j.bbamcr.2024.119799 (IF: 4.6, 74/313= 23.6% in Biochemistry & Molecular Biology)
• Chiang, Y.-C., Selvam P, Liu, Y.-X., Shih, P.-C., Chen, N.-F., Kuo, H.-M., Lin, H.-Y., Wen, Z.-H., Chen, W.-F. STAT3 phosphorylation inhibitor Bt354 exhibits anti-neoplastic activity in glioblastoma multiforme cells. Environmental Toxicology. 2024. https://doi.org/10.1002/tox.24178 (IF: 4.5, 16/94= 17.0% in Toxicology)
• Shih, P.-C., Naganuma, M., Tsuji G., Demizu, Y., Naito, M. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. Bioorganic and Medicinal Chemistry. 2023. https://doi.org/10.1016/j.bmc.2023.117507 (IF: 3.5, 12/52 = 23.1% in Organic Chemistry)
• Shih, P.-C., Naganuma, M., Demizu, Y., Naito, M. Current status of oligonucleotide-based protein degraders. Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15030765 (IF: 5.4, 51/277= 18.2% in Pharmacology & Pharmacy)
• Wen, Z.-H.*, Kuo, H.-M.*, Shih, P.-C.*, Hsu, L.-C., Chuang, J. M.-J., Chen, N.-F., Sun, H.-W., Liu, H.-T., Sung, C.-S., Chen, W.-F. Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells. Biomedicine & Pharmacotherapy. 2023 https://doi.org/10.1016/j.biopha.2023.114359 (IF: 7.5, 23/277= 8.1% in Pharmacology & Pharmacy)
*The authors contributed equally.
• Mao, Y.-W., Lu, L.-P., Shih, P.-C., Hsiao, J.-F., Wu, V., Tsai, G. E. Ultrapure and potent tannic acid (UPPTA) is a novel inhibitor of D-amino acid oxidase to improve the N-methyl-D-aspartate function of CNS disorders. Phytomedicine 
• Hsu S.-Y., Wen, Z.-H., Shih, P.-C., Kuo, H.-M., Lin, S.-C., Liu, H.-T., Lee, Y.-H., Wang, Y.-J., Chen, W.-F., Chen, N.-F. Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells. Antioxidants. 2022; https://doi.org/10.3390/antiox11081433 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)
• Kuo, T.-J., Jean, Y.-H., Shih, P.-C., Cheng, S.-Y., Kuo, H.-M., Lee, Y.-T., Lai, Y.-C., Tseng, C.-C., Chen, W.-F., and Wen, Z.-H. Stellettin B Induces Autophagic Cell Death and Apoptosis through Endoplasmic Reticulum in Human Oral Cancer. International Journal of Molecular Sciences. 2022; https://doi.org/10.3390/ijms23158813 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)
• Shih, P.-C.*, Mao, Y.-W.*, Hu, J.-W.*, Hsieh, H.-Y.*, Shih, T.-M.*, Lu, L.-P.*, Chang, W.-H.*, Huang, C.-H.*, Lin, C.-H.*, Lin, C.-H., Tan, P., Yang, Y.-C., Chien, M.-H., Su, C.-C., Ye, C.-H., Chuang, P.-Y., Hsieh, T.-L., Wang, C.-C., Hsieh, P.-S., Chou, T.-Y., Tsai, G. E. Development of the ultrapure and potent tannic acid as an orally bioavailable, pancoronal antiviral therapeutic. ACS Pharmacology & Translational Science. 2022; https://doi.org/10.1021/acsptsci.1c00264 (IF: 6.0, 25/366=6.8% in Pharmacology & Pharmacy) (被選為期刊封面、臨床試驗NCT04911777的臨床前數據發表)
*The authors contributed equally.
• Shih, P.-C.# The role of the STAT3 signaling transduction pathways in radioresistance. Pharmacology & Therapeutics. 2022; https://doi.org/10.1016/j.pharmthera.2022.108118 (IF: 13.5, 7/277=2.3% in Pharmacology & Pharmacy)
#First author and corresponding author.
• Chen, Y.-P.*, Shih, P.-C.*, Feng, C.-W., Wu, C.-C., Tsui, K.-H., Lin, Y.-H., Kuo, H.-M., and Wen, Z.-H. Pardaxin activates excessive mitophagy and mitochondria-mediated apoptosis in human ovarian cancer by inducing reactive oxygen species. Antioxidants. 2021; https://doi.org/10.3390/antiox10121883 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)
*The authors contributed equally.
• Lin, C.-H., Shih, P.-C., Tsai, G. E. Perspective Chapter: NMDA Treatments for CNS Disorders under the book title Ketamine Revisited - New Insights into NMDA Inhibitors. IntechOpen. 2021
• Ko, C.-Y.*, Shih, P.-C.*, Huang, P.-W., Lee, Y.-H., Chen, Y.-F., Tai M.-H., Liu, C.-H., Wen, Z.-H., Kuo, H.-M. Sinularin, an anti-cancer agent causing mitochondria-modulated apoptosis and cytoskeleton disruption in human hepatocellular carcinoma. International Journal of Molecular Sciences.2021; https://doi.org/10.3390/ijms22083946 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)
*The authors contributed equally.
• Shih, P.-C.#, Mei, K.-C. Role of STAT3 signaling transduction pathways in cancer stem cell-associated chemoresistance. Drug Discovery Today.2021; https://doi.org/10.1016/j.drudis.2020.11.032 (IF: 7.4, 24/277= 8.5 % in Pharmacology & Pharmacy)
#First author and corresponding author.
• Yuan, C.-H.*, Ma, Y.-L.*, Shih, P.-C.*, Chen, C.-T., Cheng, S.-Y., Pan, C.-Y., Jean, Y.-H., Chu, Y.-M., Lin, S.-C, Lai, Y,-C., Kuo, H,-M. The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells. Biochemical Pharmacology. 2020;. doi: 10.1016/j.bcp.2020.114064 (IF: 5.8, 40/277 = 14.3% in Pharmacology & Pharmacy)
*The authors contributed equally.
• Chen, Y.-F.*, Shih, P.-C.*, Kuo, H.-M.*, Yang, S.-N., Lin, Y.-Y., Chen, W.-F., Tzou, S.-J., Liu, H.-T., Chen, N.-F. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment. Cancer Medicine. 2020;. doi: 10.1002/cam4.3005 (IF: 4.0, 96/241 = 39.6% in Oncology)
*The authors contributed equally.
• Shih, P.-C.# Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains. Life Sciences. 2019; doi: 10.1016/j.lfs.2019.117241 (IF: 6.1, 35/277 = 12.5% in Pharmacology & Pharmacy)
#First author and corresponding author.
• Shih, P.-C., Yang, Y., Parkinson, G. N., Wilderspin, A. & Wells, G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 2018; doi: 10.18632/oncotarget.26013 
NSTC grants
國科會計畫
112 離體發展高安全性、有效性並具臨床潛力的新穎STAT3蛋白質降解藥物
113-115 以新穎藥理機制離體開發抗神經性疼痛藥物
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