賴至人 助理教授
研究領域：mRNA疫苗、mRNA癌症治療、癌症轉移機制、血管新生研究、CRISPR基因剪輯
最高學歷：國立清華大學生物科技所 博士
E-mail：cjlai0308@mail.nsysu.edu.tw / krad0127@gmail.com
連絡電話：07-5252000 #7209
辦公室：IR5011-1
個人網頁：ORCID
| 學經歷 | ||||||||||||||||
| 國立清華大學生物科技所 博士 | 2015.9-2019.7 | |||||||||||||||
| 國立陽明交通大學藥學系 博士後研究員 | 2019.9-2020.3 | |||||||||||||||
| University of Southern California 博士後研究員 | 2020.4-2020.7 | |||||||||||||||
| Cleveland Clinic 博士後研究員 | 2020.7-2024.6 | |||||||||||||||
| 專業 | ||||||||||||||||
| mRNA疫苗、mRNA癌症治療、癌症轉移機制、血管新生研究、CRISPR基因剪輯 | ||||||||||||||||
| 學術榮譽 | ||||||||||||||||
| Acknowledgment of Journal of Virology Ad Hoc Reviewers | 2022 | |||||||||||||||
| Department of Cancer Biology Trainee Award-3rd place winner | 2022 | |||||||||||||||
| 中華民國斐陶斐學會榮譽會員 | 2019 | |||||||||||||||
| 國立清華大學生科院聯合研討會口頭報告獎 Award 2018, UK | 2019 | |||||||||||||||
| 沈巨塵基金會論文發表獎學金 | 2018 | |||||||||||||||
| 國立清華大學-國衛院聯合研討會口頭報告獎 | 2017 | |||||||||||||||
| 講授科目 | ||||||||||||||||
| • 血管新生與癌症轉移治療 | ||||||||||||||||
| • mRNA藥物應用於新興病毒與癌症疫苗 | ||||||||||||||||
| • 疫苗開發專題研究 | ||||||||||||||||
| • 藥物開發通論 | ||||||||||||||||
| • 分子病毒學 | ||||||||||||||||
| • 書報討論 | ||||||||||||||||
| 專利及專書 | ||||||||||||||||
| U.S. Patent Application No. 18/701,156, Jae U. Jung and Chih-Jen Lai, mRNA VACCINE DESIGN VIA THE ALTERATION OF CODON USAGE. | ||||||||||||||||
| 期刊論文 | ||||||||||||||||
| 1. Kim D, Lai CJ, Cha I, Jung JU. Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development. Viruses. 2024, 16(1), 128 (IF: 4.7) | ||||||||||||||||
| 2. Lai CJ, Kim D, Kang SM, Li K, Cha I, Sasaki A, Porras J, Xia T, Jung JU. Viral codon optimization on SARS CoV-2 Spike boosts immunity in the development of COVID-19 mRNA vaccines. J Med Virol. 2023 Jan;95(10): e29183. (IF: 12.7) | ||||||||||||||||
| 3. Kim D, Lai CJ#, Cha I, Kang S, Yang WS, Choi Y, Jung JU. SFTSV Gn-Head mRNA vaccine confers efficient protection against lethal viral challenge. J Med Virol. 2023 Nov;95(11): e29203. (IF: 12.7) # (co-first author) | ||||||||||||||||
| 4. Kim D, Kim E, Kim S, Chung Y, Lai CJ, Cha I, Cho SD, Choi Y, Dai X, Kim S, Kang S, Kwak MJ, Liu Z, Choi Y, Park SH, Choi YK, Jung JU. Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets. mBio. 2023 Sep 15;14(5): e0186823 (IF: 6.4) | ||||||||||||||||
| 5. Song J, Jeong BS, Kim SW, Im SB, Kim S, Lai CJ, Cho W, Jung JU, Ahn MJ, Oh BH. Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity. Elife. 2023 May 30;12: e81646 (IF: 8.713) | ||||||||||||||||
| 6. Xia T, Wu X, Hong E, Jung K, Lai CJ, Kwak MJ, Seo HD, Kim S, Jiang ZY, Cha I, Jung JU. Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion. PLoS Pathog. 2023 Mar; 19(3): e1011232 (IF: 6.7) | ||||||||||||||||
| 7. Jeong BS, Jeon JY, Lai CJ, Yun HY, Jung JU, Oh BH. Structural basis for the broad and potent cross reactivity of an N501Ycentric antibody against sarbecoviruses. Front Immunol. 2022 Nov 17;13:1049867 (IF: 7.3) S.-C., Liu, H.-T., Lee, Y.-H., Wang, Y.-J., Chen, W.-F., Chen, N.-F. Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells. Antioxidants. 2022; https://doi.org/10.3390/antiox11081433 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal) | ||||||||||||||||
| 8. Ho CH, Chen ML, Huang HL, Lai CJ, Liu CH, Chuu CP, Lin YH. Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer. Mar Drugs. 2022 Sep 20 (9), 542. (IF: 5.4) Kuo, H.-M., Lee, Y.-T., Lai, Y.-C., Tseng, C.-C., Chen, W.-F., and Wen, Z.-H. Stellettin B Induces Autophagic Cell Death and Apoptosis through Endoplasmic Reticulum in Human Oral Cancer. International Journal of Molecular Sciences. 2022; https://doi.org/10.3390/ijms23158813 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology) | ||||||||||||||||
| 9. Choi UY, Lee JJ, Park A, Jung KL, Lee SA, Choi YJ, Lee HR, Lai CJ, Eoh H, Jung JU. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance. Cell Rep 2022 Aug 16;40(7):111234. (IF: 8.8) | ||||||||||||||||
| 10. Kim YI, Kim D, Yu KM, Seo HD, Lee SA, Casel MAB, Jang SG, Kim S, Jung W, Lai CJ, Choi YK, Jung JU. Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV- 2 Infection in Ferrets. mBio. 2021 Mar 2;12(2) (IF: 6.4) | ||||||||||||||||
| 11. Chen ML, Lai CJ, Lin YN, Huang CM, Lin YH. Multifunctional nanoparticles for targeting the tumor microenvironment to improve synergistic drug combinations and cancer treatment effects. J Mater Chem B. 2020 Dec 7;8(45):10416-10427. (IF: 7.0) | ||||||||||||||||
| 12. Lai CJ, Lin CY, Liao WY, Hour TC, Wang HD, Chuu CP. CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling. Cells. 2019 Mar 30;8(4). (IF:6.0) | ||||||||||||||||
| 13. Lai CJ, Cheng HC, Lin CY, Huang SH, Chen TH, Chung CJ, Chang CH, Wang HD, Chuu CP. Activation of liver X receptor suppresses angiogenesis via induction of ApoD. FASEB J. 2017 Dec;31 (12):5568-5576. (IF:4.8) | ||||||||||||||||
| 14. Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WS, Chang CR, Chuu CP. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. Int J Mol Sci. May 2015 (IF: 5.6) | ||||||||||||||||
| 研究計畫、國科會計畫、產學合作計畫 | ||||||||||||||||
| 申請中… | ||||||||||||||||
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