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Dr. Chih-Jen Lai Assistant Professor

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Dr. Chih-Jen Lai  Associate Professor

Research Areas: mRNA vaccine, mRNA therapeutics for cancer, Cancer metastasis, Angiogenesis, CRISPR gene editing

E-mail: cjlai0308@mail.nsysu.edu.tw

Web Page: ORCID

Room: IR5011-1

Tel: 07-5252000 #7209

Education & Positions & Employments
Ph.D., Institute of Biotechnology, National Tsing Hua University 2015.9-2019.7
Postdoctoral Fellow, Department of Pharmacy, National Yang Ming Chiao Tung University  2019.9-2020.3
Postdoctoral Fellow, University of Southern California 2020.4-2020.7
Postdoctoral Fellow, Cleveland Clinic  2020.7-2024.6
Specialty
mRNA vaccines, mRNA cancer therapeutics, Cancer metastasis, Angiogenesis, CRISPR/Cas9 gene editing Degrader Drug Discovery and Development, Medicinal Chemistry, Targeted Protein Degradation
Honors & Awards
Acknowledgment of Journal of Virology Ad Hoc Reviewers 2022
Department of Cancer Biology Trainee Award-3rd place winner for the Promotion of Science, Japan 2022
The Phi Tau Phi Scholastic Honor Society of the Republic of China (Taiwan)-Honorary Membership 2019
NTHU College of Life science Graduate Student Symposium - Honorable Mention of Oral Presentation 2019
Shen's Culture & Education Foundation Scholarship- Paper Award for Publication 2018
NHRI-NTHU Joint Research Conference – Honorable Mention of Oral Presentation 2017
Courses
• Investigation of angiogenesis and metastasis for cancer therapy
• mRNA-based therapeutics for emerging viruses and cancers
• Independent study in vaccine development (I)
• General theory of drug discovery
• Molecular virology
• SEMINAR
Patents
U.S. Patent Application No. 18/701,156, Jae U. Jung and Chih-Jen Lai, mRNA VACCINE DESIGN VIA THE ALTERATION OF CODON USAGE.
Selected publication
1. Kim D, Lai CJ, Cha I, Jung JU. Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development. Viruses. 2024, 16(1), 128 (IF: 4.7)
2. Lai CJ, Kim D, Kang SM, Li K, Cha I, Sasaki A, Porras J, Xia T, Jung JU. Viral codon optimization on SARS CoV-2 Spike boosts immunity in the development of COVID-19 mRNA vaccines. J Med Virol. 2023 Jan;95(10): e29183. (IF: 12.7)
3. Kim D, Lai CJ#, Cha I, Kang S, Yang WS, Choi Y, Jung JU. SFTSV Gn-Head mRNA vaccine confers efficient protection against lethal viral challenge. J Med Virol. 2023 Nov;95(11): e29203. (IF: 12.7) # (co-first author)
4. Kim D, Kim E, Kim S, Chung Y, Lai CJ, Cha I, Cho SD, Choi Y, Dai X, Kim S, Kang S, Kwak MJ, Liu Z, Choi Y, Park SH, Choi YK, Jung JU. Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets. mBio. 2023 Sep 15;14(5): e0186823 (IF: 6.4)
5. Song J, Jeong BS, Kim SW, Im SB, Kim S, Lai CJ, Cho W, Jung JU, Ahn MJ, Oh BH. Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity. Elife. 2023 May 30;12: e81646 (IF: 8.713)
6. Xia T, Wu X, Hong E, Jung K, Lai CJ, Kwak MJ, Seo HD, Kim S, Jiang ZY, Cha I, Jung JU. Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion. PLoS Pathog. 2023 Mar; 19(3): e1011232 (IF: 6.7)
7. Jeong BS, Jeon JY, Lai CJ, Yun HY, Jung JU, Oh BH. Structural basis for the broad and potent cross reactivity of an N501Ycentric antibody against sarbecoviruses. Front Immunol. 2022 Nov 17;13:1049867 (IF: 7.3) S.-C., Liu, H.-T., Lee, Y.-H., Wang, Y.-J., Chen, W.-F., Chen, N.-F. Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells. Antioxidants. 2022; https://doi.org/10.3390/antiox11081433 (IF: 7.0, 6/60 = 10% in Chemistry, Medicinal)
8. Ho CH, Chen ML, Huang HL, Lai CJ, Liu CH, Chuu CP, Lin YH. Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer. Mar Drugs. 2022 Sep 20 (9), 542. (IF: 5.4) Kuo, H.-M., Lee, Y.-T., Lai, Y.-C., Tseng, C.-C., Chen, W.-F., and Wen, Z.-H. Stellettin B Induces Autophagic Cell Death and Apoptosis through Endoplasmic Reticulum in Human Oral Cancer. International Journal of Molecular Sciences. 2022; https://doi.org/10.3390/ijms23158813 (IF: 5.6, 66/285 = 23% in Biochemistry & Molecular Biology)
9. Choi UY, Lee JJ, Park A, Jung KL, Lee SA, Choi YJ, Lee HR, Lai CJ, Eoh H, Jung JU. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance. Cell Rep 2022 Aug 16;40(7):111234. (IF: 8.8)
10. Kim YI, Kim D, Yu KM, Seo HD, Lee SA, Casel MAB, Jang SG, Kim S, Jung W, Lai CJ, Choi YK, Jung JU. Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV- 2 Infection in Ferrets. mBio. 2021 Mar 2;12(2) (IF: 6.4)
11. Chen ML, Lai CJ, Lin YN, Huang CM, Lin YH. Multifunctional nanoparticles for targeting the tumor microenvironment to improve synergistic drug combinations and cancer treatment effects. J Mater Chem B. 2020 Dec 7;8(45):10416-10427. (IF: 7.0)
12. Lai CJ, Lin CY, Liao WY, Hour TC, Wang HD, Chuu CP. CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling. Cells. 2019 Mar 30;8(4). (IF:6.0)
13. Lai CJ, Cheng HC, Lin CY, Huang SH, Chen TH, Chung CJ, Chang CH, Wang HD, Chuu CP. Activation of liver X receptor suppresses angiogenesis via induction of ApoD. FASEB J. 2017 Dec;31 (12):5568-5576. (IF:4.8)
14. Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WS, Chang CR, Chuu CP. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. Int J Mol Sci. May 2015 (IF: 5.6)
NSTC grants
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